Roles of Cyclin Dependent Kinase and Cdk- Activating Kinase in Cell Cycle Regulation: Contemplation of Intracellular Interactions and Functional Characterization
نویسندگان
چکیده
Cyclin dependent protein kinases (CDKs) play vital role in gene expression and cell cycle regulation. CDKs require cyclin binding activity, phosphorylation through CDK activating kinase (CAK), Cdc25, Wee 1 kinase. Non-cyclin CDK activators include CDK5 activators, Viral Cyclins and RINGO/Speedy. Among all CDK activators, CAK carries prime importance. The time frame of activating phosphorylation varies across different model organisms. A literature search was performed via using
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